Disodium Monophosphate
sodium hydrogen phosphate
CAS: 7558-79-4
Molecular Formula: H4NaO4P
Disodium Monophosphate - Names and Identifiers
Disodium Monophosphate - Physico-chemical Properties
| Molecular Formula | H4NaO4P |
| Molar Mass | 121.99 |
| Density | 1.064g/mLat 20°C |
| Melting Point | 243-245 °C |
| Water Solubility | >=10 g/100 mL at 20 ºC |
| Solubility | H2O: 0.5M at20°C, clear, colorless |
| Vapor Presure | 0Pa at 20℃ |
| Vapor Density | 4.9 (vs air) |
| Appearance | White crystalline powder |
| Color | White |
| Maximum wavelength(λmax) | ['λ: 260 nm Amax: 0.019', , 'λ: 280 nm Amax: 0.016'] |
| Merck | 14,8659 |
| pKa | (1) 2.15, (2) 6.82, (3) 12.38 (at 25℃) |
| PH | 8.9-9.2 (25℃, 50g/L in water) |
| Storage Condition | Store at +5°C to +30°C. |
| Stability | Stable. Incompatible with strong acids. Hygroscopic. |
| Sensitive | Hygroscopic |
| MDL | MFCD00003496 |
| Physical and Chemical Properties | White powder, flakes or granules. Soluble in water, its aqueous solution is alkaline; Insoluble in alcohol. |
| Use | Used as water softener, fabric weighting agent, fire retardant, and used in glaze, solder, medicine, pigment, food industry and the preparation of other phosphate Used as industrial water treatment agent, printing and dyeing detergent, quality improver, neutralizer, antibiotic culture agent, biochemical treatment agent food quality improver |
Disodium Monophosphate - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S24/25 - Avoid contact with skin and eyes. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| RTECS | WC4500000 |
| FLUKA BRAND F CODES | 3 |
| TSCA | Yes |
| HS Code | 28352200 |
| Toxicity | LD50 orally in Rabbit: > 2000 mg/kg |
Disodium Monophosphate - Upstream Downstream Industry
| Raw Materials | Sodium carbonate White phosphorus Phosphoric acid Sulfuric acid Sodium hydroxide Sodium hydroxide Sodium carbonate |
Disodium Monophosphate - Reference
| Reference Show more | 1. Li Xiaoshuang, Wei Yuping, Wang Qingqing et al. Effect of multi-component selection of freeze-dried preparation system on collapse temperature [J]. Journal of Shandong University (Natural Science Edition) 2012 47(7):10-13. 2. Li Chunlong, Li Xiaoshuang, Xu Xia. Simulation and visual measurement of system pH during freeze-drying [J]. Journal of Shandong University (Natural Science Edition) 2013(05):39-42. 3. Liang Xinhe, Wang Tao, du Yanjia, et al. Optimization of extraction technology of hypoglycemic components from Birch antler and corn silk by orthogonal experiment [J]. Jilin traditional Chinese medicine, 2019. 4. Zhang ningying, Chen Haiyan, Chen Hangjun. Effects of Ozone treatment on storage quality and antioxidant enzyme activities of blueberry [J]. Chinese Journal of Food Science, 2017, 17(008):170-176. 5. Dehai Li, Xiaoran Zhu, Lu Wang, et al. Salting-out assisted enzymatic extraction of Aralia saponin and its antioxidant activity [J]. Modern food science and technology, 2018, v.34;No.232(12):31 135-142. 6. Wang Xinran, Liu Yao, Zhang Xiaorui, etc. Composition and antioxidant activity of walnut valve extract in vitro and its effect on mutton preservation [J]. Food and Fermentation Industries, 2019, 045(010):78-85. 7. Li Na, Huang Huaisheng, Zhong Xinggang, Su in this paper. Analysis of tea quality of tea variety xiaoxianghong 21-3 under improved conditions [J]. Tea communication, 2020,47(03):427-432. 8. Shuaishiai Yan, Hongjun Shao, Zhihao Zhou, Qi Wang, Luhua Zhao, Xingbin Yang, Non-extractable polyphenols of green tea and their antioxidant, anti-α-glucosidase capacity, and release duration, journal of Functional Foods, Volume 42, 2018, 9. [IF = 4.451] Shuaishuai Yan et al."Non-extractable polyphenols of green tea and their antioxidant, anti-α-glucosidase capacity, and release during in vitro digestion."J Funct Foods. 2018 Mar;42:129 10. [IF=3.638] Zhenbao Zhu et al."Ultrasound improving the physical stability of oil-in-water emulsions stabilized by almond proteins."J Sci Food Agr. 2018 Aug;98(11):4323-4330 11. [IF=1.984] Meng Niu et al."Effects of Inorganic Phosphates on the Thermodynamic, Pasting, and Asian Noodle-Making Properties of Whole Wheat Flour."Cereal Chem. 2014 Jan;91(1):1-7 12. [IF=9.147] Yizhou Xu et al."Comparative study of whey protein isolate and gelatin treated by pH-shifting combined with ultrasonication in loading resveratrol."Food Hydrocolloid. 2021 Aug;117:106694 13. [IF=4.616] Mengru Ti et al."A ratiometric nanoprobe based on carboxylated graphitic carbon nitride nanosheets and Eu3 for the detection of tetracyclines."Analyst. 2021 Feb;146(3):1065-1073 14. [IF=2.998] Peng Fei et al.A novel fluorescence internal filtration immunoassay for the detection of clenbuterol.European Food Research And Technology.2021 Nov 17 |
Disodium Monophosphate - Nature
Open Data Verified Data
white powder, flakes or granules. Soluble in water, its aqueous solution is alkaline; Insoluble in alcohol. Deliquescence. Exposure to moist air absorbs moisture to form two-water to seven-water.
Last Update：2024-01-02 23:10:35
Disodium Monophosphate - Preparation Method
Open Data Verified Data
spray drying method: add disodium hydrogen phosphate dihydrate to the solution solution tank for heating and dissolving, add a small amount of industrial phosphoric acid, adjust the pH value of 8.8~9.0, the solution temperature of 80~85 ℃, pump to the metering tank, the atomizer is atomized by a two-flow steam-driven nozzle with a steam pressure of 0. 15~0. 3MPa, atomizer steam guide angle and the level of 30., Vapor-liquid ratio (0.4~5):1. Hot gas inlet temperature of 650~750. Can be parallel flow drying, can also be countercurrent drying. Such as countercurrent drying, the inlet temperature of 620~650 deg C, the outlet temperature of 140~150 deg C. The particle size of the finished product is about 90um, accounting for 60%, and the moisture content is <1%. The finished product of anhydrous disodium hydrogen phosphate was obtained.
Last Update：2022-01-01 11:03:05
Disodium Monophosphate - Standard
Authoritative Data Verified Data
This product is calculated according to the dry product, containing less than 99.0% of Na2HP04F.
Last Update：2024-01-02 23:10:35
Disodium Monophosphate - Trait
Authoritative Data Verified Data
- This product is white or off-white powder with hygroscopicity.
- This product is soluble in water and almost insoluble in ethanol.
Last Update：2022-01-01 11:20:43
Disodium Monophosphate - Use
Open Data Verified Data
used as fabric, wood, paper flame retardant, silk weighting agent. It is an auxiliary in the manufacture of reactive dyes. It is used instead of borax in welding and brazing.
Last Update：2022-01-01 11:03:06
Disodium Monophosphate - Differential diagnosis
Authoritative Data Verified Data
The product of aqueous solution of sodium salt and phosphate identification reaction (General 0301).
Last Update：2022-01-01 11:20:44
Disodium Monophosphate - Safety
Open Data Verified Data
should be stored in a cool, ventilated, dry warehouse. It is not appropriate to pile up the open-air cargo yard. They shall not be co-stored with moist or toxic substances. Avoid rain and sun exposure during transport. When loading and unloading should be light to prevent packaging damage. Packed in polypropylene woven bags lined with polyethylene plastic bags, each with a net weight of 50kg. The words "Avoid Heat" and "prevent moisture" shall be printed on the package. When there is a fire, it can be suppressed by using water, sand and fire extinguisher.
Last Update：2022-01-01 11:03:06
Disodium Monophosphate - Exam
Authoritative Data Verified Data
alkalinity
take the product l.O g, add water 20ml to dissolve, according to the law to determine (General 0631),p H value should be 9 .0~9. 4. The clarity and color of the solution take the product l.O g, add water 10m], fully shake to dissolve, check according to law (General rule 0901 and general rule 0902), the solution should be clear and colorless.
chloride
Take 5.0g of this product and check it according to law (General rule 0801). Compared with the control solution made of 5. 0ml of standard sodium chloride solution, it should not be more concentrated (0.001%).
sulfate
take 0802g of this product and check it according to law (General rule 0.01%). Compared with the control solution made of 2. 0ml of standard potassium sulfate solution, it should not be more concentrated ().
carbonate
take 2.0g of this product, add 10ml of water, boil, cool, add 2ml of hydrochloric acid, no bubbles should be generated.
insoluble in water
take 20.0g of this product, heat 100ml of water to dissolve, filter with No. 4 vertical melting crucible dried to constant weight by 1 0 5 1, and wash the precipitate with 200ml of hot water for 10 times, after drying at 105 ° C. For 2 hours, the remaining residue should not exceed 10mg(0. 05%).
reducing substances
Take 5.0g of this product, add fresh boiling cold water to dissolve and dilute to 50ml, shake, Take 5. 0ml, add dilute sulfuric acid 5M l and potassium permanganate titration solution (0 .0 2M d /L )0 .2 5ml, heated in a water bath for 5 minutes, the solution of the purple color should not disappear.
sodium dihydrogen phosphate
take the determination results under the content determination item and calculate according to the following formula. The content of sodium dihydrogen phosphate shall not exceed 2.5%.
loss on drying
take this product, in 130X; Dry to constant weight, weight loss should not exceed 1.0% (General rule 0831).
Iron Salt
take this product 0. Add hydrochloric acid solution (1-2) lm + and 10% sulfosalicylic acid solution (2ml), shake well, add ammonia test solution (5 m l), shake well, if color is developed, compared with standard iron solution (General rule 08 0 7 )l_0m l, the control solution made by the same method should not be deeper (0.002%).
Heavy metals
take this product 2. 0g, after adding 15ml of water to dissolve, add an appropriate amount of hydrochloric acid to adjust the solution p H value to about 4, and add acetate buffer (pH 3 .5 )2m l and water should be adjusted to 2 5 m l, which shall be checked according to law (General Principles 0821 first law), and heavy metal content shall not exceed 10 parts per million.
arsenic salt
take this product l .O g, add water 23ml dissolved, add hydrochloric acid 5ml, according to the law inspection (General Principles 0822 first law), should comply with the provisions (0.0002%).
Last Update：2022-01-01 11:20:45
Disodium Monophosphate - Content determination
Authoritative Data Verified Data
take this product about 2 .5G, precision weighing, adding fresh boiling cold water 25ml to dissolve, precision adding human hydrochloric acid titration solution (lm o l/L ) 25ml, according to the potential titration method (General rule 0701), titrate with sodium hydroxide titration solution (lm o l/L), record the volume of sodium hydroxide titration solution consumed at the first sudden jump point and the total volume of sodium hydroxide titration solution consumed at the second sudden jump point, the content was calculated as the volume of sodium hydroxide titration liquid consumed at the first burst point, and the results of the titration were corrected for JV3 using a blank test. Each lm l of hydrochloric acid titration solution (lm o l/L) corresponds to 142 mg of Na2 HPO,.
Last Update：2022-01-01 11:20:45
Disodium Monophosphate - Category
Authoritative Data Verified Data
pharmaceutical excipients, p H value regulator and buffer.
Last Update：2022-01-01 11:20:45
Disodium Monophosphate - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 11:20:46
Disodium Monophosphate - Reference Information
| FEMA | 2398 | DISODIUM PHOSPHATE |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Introduction | disodium hydrogen phosphate is an important chemical raw material in biological fermentation, food, medicine, feed, there is a wide range of applications in industrial sectors such as chemical and agricultural industries. The manufacturing methods of disodium hydrogen phosphate mainly include neutralization method, extraction method, ion exchange method, double decomposition method, direct method, crystallization method and electrolysis method. |
| properties | a colorless transparent monoclinic prismatic crystal with a relative density of 1.52, which is easily weathered in the air, it is easy to lose five molecules of crystal water and form seven water (Na2HPO4.7H2O). Soluble in water, insoluble in alcohol. The aqueous solution is slightly alkaline (PH of 0.1-1N solution is about 9.0). The water of crystallization is lost at 100 °c to form an anhydrate, which is decomposed to sodium pyrophosphate at 250 °c. |
| Use | disodium hydrogen phosphate can be used as water softener, fabric weighting agent, fire retardant, and used in glaze, solder, medicine, pigment, the food industry and the production of other phosphates. Emulsifier quality improver, nutrition enhancer, fermentation aid, chelating agent, stabilizer. Used as a boiler water softener, fabric, wood and paper flame retardant, glaze and welding agent. Used in the production of detergents, cleaning agents for printing plates and mordant for dyeing. In the printing and dyeing industry, it is used as a stabilizer for hydrogen peroxide bleaching, a filler for rayon (to enhance the strength and elasticity of silk). Is the production of sodium pyrophosphate and other phosphate raw materials, but also monosodium glutamate, erythromycin, penicillin, streptomycin and sewage production and treatment products, such as culture agent. Also used for electroplating, leather. In the food industry as a quality improver, PH regulator, nutrition enhancer, used as industrial water treatment agent, printing and dyeing detergent, quality improver, antibiotic culture agent, biochemical treatment agent, etc. used as fabric, wood, paper flame retardant, silk weighting agent. It is an auxiliary in the manufacture of reactive dyes. It is used instead of borax in welding and brazing. used as food quality improver used as analytical reagent, buffer, water softener and flame retardant in printing and dyeing industry, also used for fabric weight gain and so on used as analytical reagent and pH Reference Reagent used as flame retardant for wood, paper and fabric, glaze and flux, dyeing mordant, hydrogen peroxide bleaching stabilizer, boiler water softener, etc. used as water softener, fabric weighting agent, fire retardant, and used in glaze, solder, medicine, pigment, food industry and preparation of other phosphate Used as industrial water treatment agent, printing and dyeing detergent, quality improver, neutralizer, antibiotic culture agent, biochemical treatment agent food quality improver used in ICP-AES, AAS, AFS, ICP-MS, ion chromatography, etc. Standard solutions were used for titration analysis. |
| production method | spray drying method: add disodium hydrogen phosphate dihydrate into the dissolution tank to heat and dissolve, add a small amount of industrial phosphoric acid, adjust pH 8.8-9.0, the temperature of the solution is 80-85 ℃, which is pumped to the metering tank and atomized by the atomizer. The atomizer is a two-flow type steam-driven nozzle with a steam pressure of 0.15-0.3 Mpa, and the steam guiding angle of the atomizer is 30 ° to the horizontal level, vapor-liquid ratio (0.4~5):1. Hot gas inlet temperature of 650 -- 750 deg C. Can be parallel flow drying, can also be countercurrent drying. Such as countercurrent drying, the inlet temperature of 620-650 deg C, the outlet temperature of 140~150 deg C. The particle size of the finished product is about 90 μm, accounting for 60%, and the moisture content is <1%. The finished product of anhydrous disodium hydrogen phosphate was obtained. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:01:54
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View History
Disodium Monophosphate
A,A-DICHLORO-O-XYLENE
5'-chloro-2'-deoxyformycin A
Ethane, 1,1-dichloro-2,2-diethoxy-
Pentane-2,4-dicarboxylic acid diethyl ester
Benzaldehyde, 2-chloro-6-methoxy-
1-(TERT-BUTYL)-4-CHLORO-3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
4-Pentynoic acid, 2-[[(9H-fluoren-9-ylmethoxy)carbonyl]methylamino]-, (2S)-
3-(2-氯苯基)环丁酮
5-Fluoro-4-hydrazino-2-methoxypyrimidine
A,A-DICHLORO-O-XYLENE
5'-chloro-2'-deoxyformycin A
Ethane, 1,1-dichloro-2,2-diethoxy-
Pentane-2,4-dicarboxylic acid diethyl ester
Benzaldehyde, 2-chloro-6-methoxy-
1-(TERT-BUTYL)-4-CHLORO-3-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
4-Pentynoic acid, 2-[[(9H-fluoren-9-ylmethoxy)carbonyl]methylamino]-, (2S)-
3-(2-氯苯基)环丁酮
5-Fluoro-4-hydrazino-2-methoxypyrimidine
Raw Materials for Disodium Monophosphate